Fluorescent Calixarene-Schiff as a Nanovehicle with Biomedical Purposes

synthesis of a novel fluorescent schiff base as a possible hg and ag ions selective sensor

Calixmexitil: Calixarene-based Cluster of Mexiletine with Amplified Anti-myotonic Activity as A Novel Use-dependent Sodium Channel Blocker

Mexiletine as the first choice drug in myotonia treatment is a chiral sodium channel blocker clinically used in its racemic form. The phenolic structure of this drug, prompted us to design its novel calix[4]arene-based cluster in a chalice-shaped structure. Therefore, the present study reports the synthesis and in-vitro anti-myotonic activity of the chalice-shaped cluster of mexiletine...

Gold nanoparticles: calixarene complexation in a mixed calixarene–alkanethiol monolayer†

This paper describes a detailed study on the complexation of pyridinium derivatives with calixarenes bound to gold nanoparticles (AuNPs). The studied calixarene derivatives are mixed with alkanethiols to formmixed monolayers on AuNP surfaces. The key findings are: (i) even a small amount (less than 11 mol%) of calixarenes can retain their complexation abilities among a majority of alkanethiols ...

Optimizing a Nanovehicle for Pancreatic Cancer Treatment

Calixmexitil: Calixarene-based Cluster of Mexiletine with Amplified Anti-myotonic Activity as A Novel Use-dependent Sodium Channel Blocker

Mexiletine as the first choice drug in myotonia treatment is a chiral sodium channel blocker clinically used in its racemic form. The phenolic structure of this drug, prompted us to design its novel calix[4]arene-based cluster in a chalice-shaped structure. Therefore, the present study reports the synthesis and in-vitro anti-myotonic activity of the chalice-shaped cluster of mexiletine...